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KMID : 0356920110610030216
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Korean Journal of Anesthesiology
2011 Volume.61 No. 3 p.216 ~ p.219
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Optimal sedative dose of propofol to start MRI in children with cerebral palsy
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Kim Eun-Jung
Jo Youn-Yi
Kil Hae-Keum
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Abstract
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Background:This study was designed to determine the optimal sedative dose of propofol to start brain magnetic resonance imaging (MRI) in children with cerebral palsy (CP).
Methods:Twenty children, aged 0.5-5 years, were administered propofol to achieve a University of Michigan Sedation Scale (UMSS) score ≥ 3 in the MRI room. The proper dose of propofol was determined using the up-and-down method.
Results:The ED50 and ED95 for successful sedation with a UMSS ≥ 3 were 2.07 mg/kg (95% CI 1.69-2.56) and 2.69 mg/kg (95% CI 2.35-5.59). Respiratory events occurred in 5 patients and were resolved with neck extension, chin lift, or transient respiratory assistance with successful sedation.
Conclusions:Low dose propofol can safely facilitate the initiation of MRI in children with CP.
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KEYWORD
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Cerebral palsy, MRI, Propofol
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